A Clinical Research Study for Chronic Hepatitis B
Learn more about the B-SUPREME study for people with chronic HBV infection.
Clinical Trial Locations
Locations (58)
Information on this website is directed towards U.S. residents only.
United States
Bulgaria
Canada
China
France
Hong Kong
Italy
Moldova
New Zealand
Romania
South Korea
Spain
Taiwan
United Kingdom
About the B-Supreme Study
The B-SUPREME study is a clinical research study for people with chronic hepatitis B. We’re testing a new investigational drug called pevifoscorvir sodium to see if it works and is safe.
ELIGIBLITY CRITERIA
People who have never taken a medication for chronic hepatitis B before or stopped taking their last hepatitis B medication or experimental treatment more than six months ago may be eligible to participate in the study.
Condition
Chronic HBV Infection
Status
HBeAg+ or HBeAg-
Age
18-65
This clinical study is looking at a new investigational drug, pevifoscorvir sodium, to see if it can lower the amount of hepatitis B virus in the blood compared with a standard treatment, tenofovir disoproxil fumarate (TDF). We will also be checking to see if the investigational drug is safe and how people tolerate it. In addition, we’ll be measuring certain proteins in the blood that are markers of the hepatitis B infection.
To join the clinical study, specific requirements must be met. More details can also be found at ClinicalTrials.gov.
About pevifoscorvir sodium
Pevifoscorvir sodium (also known as ALG-000184) is a new investigational drug we are developing. It’s a pill taken once a day. We’re testing whether it will attack the hepatitis B virus by targeting its outer shell and help prevent the virus from growing and spreading.
Clinical Trial FAQ
What is an investigational drug?
An investigational drug is one that is currently being tested and is not approved for use by global regulatory agencies such as the U.S. Food and Drug Administration (FDA).
What is a clinical research study?
A clinical study, or trial, is a type of medical research that looks at how potential medicines affect the participants. These participants are volunteers. Each medicine that is approved and available today was first tested in clinical trials involving many volunteers.
What is informed consent?
Informed consent is a process that begins at the clinic (clinical site), where a study doctor or research staff will explain the purpose, procedures, potential risks and possible benefits of the clinical study, and the rights of participants.